Bioequivalence and Bioavailability Forum

Difference between actual and published PK parameters [Study Assessment]

posted by Loky do – Egypt, 2022-02-15 16:48 (1030 d 22:31 ago) – Posting: # 22785
Views: 3,511

❝ Dear dshah

agree with ElMaestro, I noticed that subjects with shorter half-lives (about 50% of total study subjects) have lower plasma concentration than other subjects with longer half-lives, this could support the fact of fast and slow metabolizers as https://www.medicines.org.uk/emc/product/1269/smpc, also I noticed that those subjects weight is lower than others with long half-lives? could it be a proper justification?

Thanks dears

Complete thread:

Difference between actual and published PK parameters Loky do 2022-02-14 16:06 [Study Assessment]
- Difference between actual and published PK parameters Helmut 2022-02-14 17:30
  - Difference between actual and published PK parameters Loky do 2022-02-15 13:20
    - Difference between actual and published PK parameters dshah 2022-02-15 15:26
      - Difference between actual and published PK parametersLoky do 2022-02-15 15:48
    - Difference between actual and published PK parameters Helmut 2022-02-15 15:56
- Difference between actual and published PK parameters dshah 2022-02-14 18:39
- Difference between actual and published PK parameters ElMaestro 2022-02-14 23:09

Difference between actual and published PK parameters [Study As­sess­ment]

Complete thread:

Difference between actual and published PK parameters [Study Assessment]