Difference between actual and published PK parameters [Study As­sess­ment]

posted by Loky do – Egypt, 2022-02-15 16:48 (345 d 19:20 ago) – Posting: # 22785
Views: 1,181

❝ Dear dshah

agree with ElMaestro, I noticed that subjects with shorter half-lives (about 50% of total study subjects) have lower plasma concentration than other subjects with longer half-lives, this could support the fact of fast and slow metabolizers as https://www.medicines.org.uk/emc/product/1269/smpc, also I noticed that those subjects weight is lower than others with long half-lives? could it be a proper justification?

Thanks dears

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