Bioequivalence and Bioavailability Forum

Difference between actual and published PK parameters [Study As­sess­ment]

posted by Loky do – Egypt, 2022-02-15 14:20 (1178 d 20:33 ago) – Posting: # 22783
Views: 4,044

Thanks Helmut for your reply , excuse my confusion, I have a question regarding dapoxetine biphasic half-life; the initial and terminal half-life (the initial half-life which is 1.3-1.5 hours and the terminal half-life which is 15-19 hours) does this biphasic nature affect the practical obtained half life of the drug? and is this nature could affect the drug variability?

Thanks

Complete thread:

• Difference between actual and published PK parameters Loky do 2022-02-14 16:06 [Study As­sess­ment] 
  • Difference between actual and published PK parameters Helmut 2022-02-14 17:30
    • Difference between actual and published PK parametersLoky do 2022-02-15 13:20
      • Difference between actual and published PK parameters dshah 2022-02-15 15:26
        • Difference between actual and published PK parameters Loky do 2022-02-15 15:48
      • Difference between actual and published PK parameters Helmut 2022-02-15 15:56
  • Difference between actual and published PK parameters dshah 2022-02-14 18:39
  • Difference between actual and published PK parameters ElMaestro 2022-02-14 23:09