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RegisterAnalytical range LOQ [Bioanalytics]
Thanks,
But when you say:
» At one extreme you may need to eliminate those subject periods that are affected, which may mean a complete loss of a subject for stats if this is a 222BE design, since only subjects who contribute with T and R should be in the stats analysis.
What is the rational for eliminating those subjects? According to my opinion excluding these subjects can not show that the subjects might have had pre-dose concentration below the LOQ with the given method. It will only reduce the power of the study, isn't it?
Edit: Standard quotes restored; see also this post #8. [Helmut]
But when you say:
» At one extreme you may need to eliminate those subject periods that are affected, which may mean a complete loss of a subject for stats if this is a 222BE design, since only subjects who contribute with T and R should be in the stats analysis.
What is the rational for eliminating those subjects? According to my opinion excluding these subjects can not show that the subjects might have had pre-dose concentration below the LOQ with the given method. It will only reduce the power of the study, isn't it?
Edit: Standard quotes restored; see also this post #8. [Helmut]
Complete thread:
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- Analytical range LOQ ElMaestro 2021-12-20 22:46
- Analytical range LOQFarmacevt 2021-12-22 22:02
- Analytical range LOQ dshah 2021-12-21 12:03
- LLOQ based on ‘worst case’ Cmax Helmut 2021-12-21 13:31
- LLOQ based on ‘worst case’ Cmax ElMaestro 2021-12-21 15:48
- LLOQ based on ‘worst case’ Cmax Helmut 2021-12-22 23:16
- LLOQ based on ‘worst case’ Cmax ElMaestro 2021-12-21 15:48
- Analytical range LOQ ElMaestro 2021-12-20 22:46
Ing. Helmut Schütz