LLOQ based on ‘worst case’ Cmax [Bioanalytics]

posted by ElMaestro  – Denmark, 2021-12-21 15:48 (277 d 09:11 ago) – Posting: # 22708
Views: 973

Hi Helmut,

did you consider plnorm in stead of simulations:

Mean=100
CV=.2
V=log(1+CV*CV)
SD.logscale=sqrt(V)
MN.logscale=log(Mean/20)-0.5*V
LLOQ=5
probablity.of.problem = 1-plnorm(LLOQ, mean=MN.logscale, sd=SD.logscale) #or use the upper tail



Did not check the equations. Assuming they are ok, I just thought I'd offer a shorthand on their basis, quick and dirty. :-)

Pass or fail!
ElMaestro

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