Bioequivalence and Bioavailability Forum

LLOQ based on ‘worst case’ Cmax [Bioanalytics]

posted by ElMaestro  – Denmark, 2021-12-21 16:48 (1273 d 16:52 ago) – Posting: # 22708
Views: 4,672

Hi Helmut,

did you consider plnorm in stead of simulations:

Mean=100
CV=.2
V=log(1+CV*CV)
SD.logscale=sqrt(V)
MN.logscale=log(Mean/20)-0.5*V
LLOQ=5
probablity.of.problem = 1-plnorm(LLOQ, mean=MN.logscale, sd=SD.logscale) #or use the upper tail



Did not check the equations. Assuming they are ok, I just thought I'd offer a shorthand on their basis, quick and dirty.

Complete thread:

• Analytical range LOQ Farmacevt 2021-12-20 20:54 [Bioanalytics] 
  • Analytical range LOQ ElMaestro 2021-12-20 22:46
    • Analytical range LOQ Farmacevt 2021-12-22 22:02
  • Analytical range LOQ dshah 2021-12-21 12:03
  • LLOQ based on ‘worst case’ Cmax Helmut 2021-12-21 13:31
    • LLOQ based on ‘worst case’ CmaxElMaestro 2021-12-21 15:48
      • LLOQ based on ‘worst case’ Cmax Helmut 2021-12-22 23:16