Invitro microbial kill rate Stat analysis [Regulatives / Guidelines]

posted by dshah  – India/United Kingdom, 2021-12-20 12:17 (158 d 04:43 ago) – Posting: # 22703
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Dear MGR!

For In vitro PD relationship- kindly view section 5 of Microbiology review. Also review- comparative article.
If you are interested for in-vivo PKPD and in vitro kill rate relationship, I am not sure but you can view some PBPK modeling which might be useful.
1. Ocular Physiologically Based Pharmacokinetic Modeling for Ointment Formulations
2. Application of Mechanistic Ocular Absorption Modeling and Simulation to Understand the Impact of Formulation Properties on Ophthalmic Bioavailability in Rabbits: a Case Study Using Dexamethasone Suspension
3. A whole-body physiologically based pharmacokinetic (WB-PBPK) model of ciprofloxacin: a step towards predicting bacterial killing at sites of infection.

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