Bioequivalence and Bioavailability Forum • what about recyclers?

what about recyclers? [NCA / SHAM]

posted by mittyri – Russia, 2021-10-04 16:22 (928 d 14:33 ago) – Posting: # 22619
Views: 2,296

Dear Helmut,

❝ More details… The reference formulation in this study was terrible; CV_wR twice of CV_wT, many subjects with low AUCs after R. Since CV_wT <30%, this was a HVDP and not a HVD. Adjusting the AUC would make things worse.

now try something with horrible enterohepatic cirulation ;-)

—
Kind regards,
Mittyri

Complete thread:

AUC · k for variable inter-occasion CL Helmut 2021-09-30 23:31 [NCA / SHAM]
- AUC · k for variable inter-occasion CL PharmCat 2021-10-01 00:15
  - Changing the regulations: Hope dies last. Helmut 2021-10-01 11:18
    - AUC * k d_labes 2021-10-01 13:52
      - AUC * k Helmut 2021-10-01 17:01
        
        AUC * k d_labes 2021-10-02 10:55
        
        Ratio/product of two lognormals Helmut 2021-10-03 20:29
        Not for HVDPs? Helmut 2021-10-04 12:05
        
        what about recyclers?mittyri 2021-10-04 14:22
        
        Oh dear! Helmut 2021-10-04 16:10
    - Changing the regulations: Hope dies last. PharmCat 2021-10-01 18:48