Bioequivalence and Bioavailability Forum

AUC * k [NCA / SHAM]

posted by d_labes  – Berlin, Germany, 2021-10-02 12:55 (1355 d 11:51 ago) – Posting: # 22614
Views: 5,381

Dear Helmut,

❝ Since both are lognormal, their ratio should be lognormal as well. I trust here Martin; will meet him in the evening and ask again.

❝ Furthermore, the distribution of values per se is not important, only the residual error.

Correct.

❝ One of my 4-period full replicate studies (143 subjects, Method A)

❝

Looks not too bad for a log-normal .

Complete thread:

• AUC · k for variable inter-occasion CL Helmut 2021-09-30 23:31 [NCA / SHAM] 
  • AUC · k for variable inter-occasion CL PharmCat 2021-10-01 00:15
    • Changing the regulations: Hope dies last. Helmut 2021-10-01 11:18
      • AUC * k d_labes 2021-10-01 13:52
        • AUC * k Helmut 2021-10-01 17:01
          • AUC * kd_labes 2021-10-02 10:55
            • Ratio/product of two lognormals Helmut 2021-10-03 20:29
            • Not for HVDPs? Helmut 2021-10-04 12:05
              • what about recyclers? mittyri 2021-10-04 14:22
                • Oh dear! Helmut 2021-10-04 16:10
      • Changing the regulations: Hope dies last. PharmCat 2021-10-01 18:48