Bioequivalence and Bioavailability Forum • AUC * k

AUC * k [NCA / SHAM]

posted by d_labes – Berlin, Germany, 2021-10-01 15:52 (1356 d 10:23 ago) – Posting: # 22611
Views: 5,415

Dear both,

what do you think is a reasonable assumption about the distribution of the metric AUC*k?
Do we have to throw away our evaluation of BE studies assuming log-normal distri of the metrics AUC and/or Cmax?

—
Regards,

Detlew

Complete thread:

AUC · k for variable inter-occasion CL Helmut 2021-09-30 23:31 [NCA / SHAM]
- AUC · k for variable inter-occasion CL PharmCat 2021-10-01 00:15
  - Changing the regulations: Hope dies last. Helmut 2021-10-01 11:18
    - AUC * kd_labes 2021-10-01 13:52
      - AUC * k Helmut 2021-10-01 17:01
        
        AUC * k d_labes 2021-10-02 10:55
        
        Ratio/product of two lognormals Helmut 2021-10-03 20:29
        Not for HVDPs? Helmut 2021-10-04 12:05
        
        what about recyclers? mittyri 2021-10-04 14:22
        
        Oh dear! Helmut 2021-10-04 16:10
    - Changing the regulations: Hope dies last. PharmCat 2021-10-01 18:48