Bioequivalence and Bioavailability Forum • AUC · k for variable inter-occasion CL

AUC · k for variable inter-occasion CL [NCA / SHAM]

posted by PharmCat – Russia, 2021-10-01 02:15 (1075 d 08:11 ago) – Posting: # 22609
Views: 3,445

Hey!
Helmut,
Sounds great. One problem ... I don't think that our regulators will be able to understand this, or there will be a desire and dare to change the foundations. Also, I think NLME modeling can be applied.

Complete thread:

AUC · k for variable inter-occasion CL Helmut 2021-09-30 23:31 [NCA / SHAM]
- AUC · k for variable inter-occasion CLPharmCat 2021-10-01 00:15
  - Changing the regulations: Hope dies last. Helmut 2021-10-01 11:18
    - AUC * k d_labes 2021-10-01 13:52
      - AUC * k Helmut 2021-10-01 17:01
        
        AUC * k d_labes 2021-10-02 10:55
        
        Ratio/product of two lognormals Helmut 2021-10-03 20:29
        Not for HVDPs? Helmut 2021-10-04 12:05
        
        what about recyclers? mittyri 2021-10-04 14:22
        
        Oh dear! Helmut 2021-10-04 16:10
    - Changing the regulations: Hope dies last. PharmCat 2021-10-01 18:48