Increased variability [GxP / QC / QA]

posted by ElMaestro  – Denmark, 2021-09-17 18:51 (39 d 11:15 ago) – Posting: # 22586
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Hi all,

» » The CVs calculated from the confidence intervals in both ‘parts’ are much lower than the ones in the ‘full’ study. Or the other way ’round: If we pool the CVs of the ‘parts’ we could expect values which are lower than the ‘observed’ (tee-hee!) ones.

Correctly observed. And for exactly those reasons it makes very good sense to plot for example the RMSE, CV, SE of diff., or even the width of the CI as function of (cumulated) number of subjects.

It is not so difficult. :-)

Pass or fail!
ElMaestro

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