Increased variability [GxP / QC / QA]

posted by Ohlbe – France, 2021-09-17 19:56 (805 d 07:46 ago) – Posting: # 22585
Views: 5,011

Hi Helmut,

❝ The CVs calculated from the confidence intervals in both ‘parts’ are much lower than the ones in the ‘full’ study. Or the other way ’round: If we pool the CVs of the ‘parts’ we could expect values which are lower than the ‘observed’ (tee-hee!) ones.


Yep. The effect on the MSE is clearly visible on Figure 4 of the paper linked by ElMaestro.

Regards
Ohlbe

Complete thread:

UA Flag
Activity
 Admin contact
22,811 posts in 4,783 threads, 1,638 registered users;
23 visitors (0 registered, 23 guests [including 4 identified bots]).
Forum time: 02:42 CET (Europe/Vienna)

Inspiration is constantly in the air.
It’s up to us to develop the sensitivity
to pick up on it.    Herbie Hancock

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5