Increased variability [GxP / QC / QA]

posted by Ohlbe – France, 2021-09-17 19:56 (1390 d 08:17 ago) – Posting: # 22585
Views: 15,621

Hi Helmut,

❝ The CVs calculated from the confidence intervals in both ‘parts’ are much lower than the ones in the ‘full’ study. Or the other way ’round: If we pool the CVs of the ‘parts’ we could expect values which are lower than the ‘observed’ (tee-hee!) ones.


Yep. The effect on the MSE is clearly visible on Figure 4 of the paper linked by ElMaestro.

Regards
Ohlbe

Complete thread:

UA Flag
Activity
 Admin contact
23,428 posts in 4,929 threads, 1,697 registered users;
45 visitors (0 registered, 45 guests [including 13 identified bots]).
Forum time: 04:13 CEST (Europe/Vienna)

If I’d observed all the rules,
I’d never have got anywhere.    Marilyn Monroe

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5