FDA: PROC MIXED (‼) for ABE [Regulatives / Guidelines]

posted by Helmut Homepage – Vienna, Austria, 2021-09-17 15:15 (281 d 00:42 ago) – Posting: # 22581
Views: 1,419

Hi Mahmoud,

» I think that using proc mixed to fit RTR/TRR/RRT design is not suitable, because in most cases proc mixed produced Estimated G matrix is not positive definite.
»
» So proc GLM recommended by FDA and Emea is more appropriate in the Semi-replicated designs

Please read the entire thread again. The FDA does recommend PROC MIXED for ABE in all guidances.
That’s the problem.

Dif-tor heh smusma 🖖 [image]
Helmut Schütz
[image]

The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes

Complete thread:

UA Flag
Activity
 Admin contact
22,166 posts in 4,645 threads, 1,572 registered users;
online 6 (0 registered, 6 guests [including 2 identified bots]).
Forum time: Saturday 15:57 CEST (Europe/Vienna)

Absolute certainty is a privilege of uneducated minds  and fanatics.
It is, for scientific folk, an unattainable ideal.    Cassius J. Keyser

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5