## FDA: PROC MIXED (‼) for ABE [Regulatives / Guidelines]

Hi Mahmoud,

» I think that using proc mixed to fit RTR/TRR/RRT design is not suitable, because in most cases proc mixed produced Estimated G matrix is not positive definite.
»
» So proc GLM recommended by FDA and Emea is more appropriate in the Semi-replicated designs

Please read the entire thread again. The FDA does recommend PROC MIXED for ABE in all guidances.
That’s the problem.

Dif-tor heh smusma 🖖
Helmut Schütz

The quality of responses received is directly proportional to the quality of the question asked. 🚮
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