Achievement of Steady State: Visual inspection & common sense [General Statistics]
❝ Run a linear regression of pre-dose concentrations vs time and test the slope against zero (or whether zero is included in the 95% CI of the slope). The former should be part of the output.
So you are essentially saying statistical relevance is not the right tool here. Agreed. Instead of relying on visual inspection & gut feeling (= common sense? ) can we define pharmacological relevance? Is there a way to define quantitative thresholds based on the PK (or even PD?) of the compound (i.e. concentration should not change by more than x%)?
- Achievement of Steady State arl_stat 2021-07-31 07:42
- Achievement of Steady State: Visual inspection & common sense Helmut 2021-07-31 10:58