Achievement of Steady State: Visual inspection & common sense [General Sta­tis­tics]

posted by Ben – 2021-08-05 08:08 (125 d 03:07 ago) – Posting: # 22509
Views: 1,529

Hi Helmut,

» Run a linear regression of pre-dose concentrations vs time and test the slope against zero (or whether zero is included in the 95% CI of the slope). The former should be part of the output.
» However, I don’t recommend it (see there).

So you are essentially saying statistical relevance is not the right tool here. Agreed. Instead of relying on visual inspection & gut feeling (= common sense? :-)) can we define pharmacological relevance? Is there a way to define quantitative thresholds based on the PK (or even PD?) of the compound (i.e. concentration should not change by more than x%)?

Best regards,
Ben.

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