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RegisterAchievement of Steady State: Visual inspection & common sense [General Statistics]
Hi Helmut,
So you are essentially saying statistical relevance is not the right tool here. Agreed. Instead of relying on visual inspection & gut feeling (= common sense?
) can we define pharmacological relevance? Is there a way to define quantitative thresholds based on the PK (or even PD?) of the compound (i.e. concentration should not change by more than x%)?
Best regards,
Ben.
❝ Run a linear regression of pre-dose concentrations vs time and test the slope against zero (or whether zero is included in the 95% CI of the slope). The former should be part of the output.
❝ However, I don’t recommend it (see here and there).
So you are essentially saying statistical relevance is not the right tool here. Agreed. Instead of relying on visual inspection & gut feeling (= common sense?
) can we define pharmacological relevance? Is there a way to define quantitative thresholds based on the PK (or even PD?) of the compound (i.e. concentration should not change by more than x%)?Best regards,
Ben.
Complete thread:
- Achievement of Steady State arl_stat 2021-07-31 07:42 [General Statistics]
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- Achievement of Steady State: Visual inspection & common sense Helmut 2021-07-31 10:58
- Achievement of Steady State: Visual inspection & common senseBen 2021-08-05 08:08
- Threshold of % change? Helmut 2021-08-05 11:43
- Threshold of % change? Ben 2021-10-17 12:16
- Keep it simple Helmut 2021-10-20 12:36
- Threshold of % change? Ben 2021-10-17 12:16
- Threshold of % change? Helmut 2021-08-05 11:43
- Achievement of Steady State: Visual inspection & common senseBen 2021-08-05 08:08
- Achievement of Steady State: Visual inspection & common sense Helmut 2021-07-31 10:58
Ing. Helmut Schütz