Achievement of Steady State: Visual inspection & common sense [General Sta­tis­tics]

posted by Ben – 2021-08-05 10:08 (547 d 08:11 ago) – Posting: # 22509
Views: 2,715

Hi Helmut,

❝ Run a linear regression of pre-dose concentrations vs time and test the slope against zero (or whether zero is included in the 95% CI of the slope). The former should be part of the output.

❝ However, I don’t recommend it (see here and there).


So you are essentially saying statistical relevance is not the right tool here. Agreed. Instead of relying on visual inspection & gut feeling (= common sense? :-)) can we define pharmacological relevance? Is there a way to define quantitative thresholds based on the PK (or even PD?) of the compound (i.e. concentration should not change by more than x%)?

Best regards,
Ben.

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