Bioequivalence and Bioavailability Forum

Hi Hötzi,

❝ Define relevant. 

Please go right ahead help me define it.
Relevance is not part of the inventory in my department.

One thing that is not explicit in the paper but which is really funny is that:

1. The individual treatment estimates are completely, utterly, terribly off with the lm.
   
2. The individual treatment estimates are very close to true with the mm.
   
3. Both give the same treatment differences as you can see in the paper.

I'd like to study the phenomenon a bit more with e.g. datasets having missing values. But on my old toaster these things run slow.

Bonus: Someone tell me how to control bobyqa convergence in a paradigm that fits into things like tolerance or relative tolerance. I don't quite get the convergence principles for that optimzer. It would help speed up experiments.