partial AUC [NCA / SHAM]

posted by Vishal S – India, 2021-08-02 09:20 (172 d 13:36 ago) – Posting: # 22491
Views: 1,616


In calculation of terminal partial AUC (AUC cut off t-tlast) specified as per EMA guideline for MR formulations
in such cases what is meaning of tlast?

is this last time of blood collection or its last time of dosing interval?

for example-In study blood collection is 72.00 hrs, However dosing interval of Drug is 24.00 hrs then early partial AUC will be AUC(0-12 hrs) & what would be the Terminal Partial AUC?

Thanks and Reagrds
Vishal S

Edit: Category changed; see also this post #1. GL linked. [Helmut]

Complete thread:

 Admin contact
21,835 posts in 4,569 threads, 1,554 registered users;
online 9 (0 registered, 9 guests [including 5 identified bots]).
Forum time: Friday 21:57 CET (Europe/Vienna)

No problem can stand the assault of sustained thinking.    Voltaire

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz