PBPK [PK / PD]

posted by Helmut Homepage – Vienna, Austria, 2021-07-01 19:09 (1077 d 15:15 ago) – Posting: # 22449
Views: 1,856

Hi pharm07,

❝ ❝ For Loo-Riegelman you require the ‘true’ elimination from an iv administration. I guess you have it.

❝ ❝ […] you cannot distinguish between liver first pass and pre-systemic first pass in the gut wall. If you are interested in them, you need PBPK.


❝ Thanks for your suggestion :-)


❝ Yes, I have an elimination value. Can you support on this, how to calculate? or how to build the model?


Did you bother reading my previous post? You can’t estimate liver first pass with a PK model. If you have – a lot of – money, go for suitable software (SymCyp, GastroPlus). Even then, there is no guarantee that it will work for your drug (I have seen terrific failures).
May I ask: What do you want to achieve?

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