PBPK [PK / PD]

posted by Helmut Homepage – Vienna, Austria, 2021-07-01 17:09 (319 d 03:28 ago) – Posting: # 22449
Views: 648

Hi pharm07,

» » For Loo-Riegelman you require the ‘true’ elimination from an iv administration. I guess you have it.
» » […] you cannot distinguish between liver first pass and pre-systemic first pass in the gut wall. If you are interested in them, you need PBPK.

» Thanks for your suggestion :-)
»
» Yes, I have an elimination value. Can you support on this, how to calculate? or how to build the model?

Did you bother reading my previous post? You can’t estimate liver first pass with a PK model. If you have – a lot of – money, go for suitable software (SymCyp, GastroPlus). Even then, there is no guarantee that it will work for your drug (I have seen terrific failures).
May I ask: What do you want to achieve?

Dif-tor heh smusma 🖖 [image]
Helmut Schütz
[image]

The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes

Complete thread:

UA Flag
Activity
 Admin contact
22,074 posts in 4,629 threads, 1,565 registered users;
online 13 (0 registered, 13 guests [including 12 identified bots]).
Forum time: Monday 20:38 CEST (Europe/Vienna)

Rules are for the guidance of wise men
and the blind obedience of fools.    attributed to Solon

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5