PBPK [PK / PD]

posted by Helmut Homepage – Vienna, Austria, 2021-06-30 12:27 (1115 d 10:06 ago) – Posting: # 22441
Views: 2,110

Hi pharm07,

❝ How to estimate liver % FPE from Loo-Riegelman (2-compartment) model deconvolution of oral cp time profile data?


For Loo-Riegelman you require the ‘true’ elimination from an iv administration. I guess you have it. However, any PK model (and deconvolution based on it) is purely empirical. There is no relationship to physiology.*
Hence, you cannot distinguish between liver first pass and pre-systemic first pass in the gut wall. If you are interested in them, you need PBPK.

[image]
Peters SA. Physiology-Based PK (PBPK). Modeling and Simulations. Wiley, 2012.




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