PBPK [PK / PD]
Hi pharm07,
For Loo-Riegelman you require the ‘true’ elimination from an iv administration. I guess you have it. However, any PK model (and deconvolution based on it) is purely empirical. There is no relationship to physiology.*
Hence, you cannot distinguish between liver first pass and pre-systemic first pass in the gut wall. If you are interested in them, you need PBPK.
❝ How to estimate liver % FPE from Loo-Riegelman (2-compartment) model deconvolution of oral cp time profile data?
For Loo-Riegelman you require the ‘true’ elimination from an iv administration. I guess you have it. However, any PK model (and deconvolution based on it) is purely empirical. There is no relationship to physiology.*
Hence, you cannot distinguish between liver first pass and pre-systemic first pass in the gut wall. If you are interested in them, you need PBPK.
Peters SA. Physiology-Based PK (PBPK). Modeling and Simulations. Wiley, 2012.
- Did you ever wonder why some drugs have a volume of distribution of hundreds (‼) of liters?
—
Dif-tor heh smusma 🖖🏼 Довге життя Україна!![[image]](https://static.bebac.at/pics/Blue_and_yellow_ribbon_UA.png)
Helmut Schütz
![[image]](https://static.bebac.at/img/CC by.png)
The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes
Dif-tor heh smusma 🖖🏼 Довге життя Україна!
![[image]](https://static.bebac.at/pics/Blue_and_yellow_ribbon_UA.png)
Helmut Schütz
![[image]](https://static.bebac.at/img/CC by.png)
The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes
Complete thread:
- Calculation of % Liver FPE pharm07 2021-06-30 05:33 [PK / PD]