PBPK [PK / PD]

posted by Helmut Homepage – Vienna, Austria, 2021-06-30 12:27 (588 d 23:32 ago) – Posting: # 22441
Views: 935

Hi pharm07,

❝ How to estimate liver % FPE from Loo-Riegelman (2-compartment) model deconvolution of oral cp time profile data?


For Loo-Riegelman you require the ‘true’ elimination from an iv administration. I guess you have it. However, any PK model (and deconvolution based on it) is purely empirical. There is no relationship to physiology.*
Hence, you cannot distinguish between liver first pass and pre-systemic first pass in the gut wall. If you are interested in them, you need PBPK.

[image]
Peters SA. Physiology-Based PK (PBPK). Modeling and Simulations. Wiley, 2012.




Dif-tor heh smusma 🖖🏼 Довге життя Україна! [image]
Helmut Schütz
[image]

The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes

Complete thread:

UA Flag
Activity
 Admin contact
22,489 posts in 4,711 threads, 1,605 registered users;
15 visitors (0 registered, 15 guests [including 5 identified bots]).
Forum time: 11:00 CET (Europe/Vienna)

Many people tend to look at programming styles and languages like religions:
if you belong to one, you cannot belong to others.
But this analogy is another fallacy.    Niklaus Wirth

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5