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RegisterPBPK [PK / PD]
posted by Helmut 
– Vienna, Austria, 2021-06-30 12:27 (1411 d 16:45 ago) – Posting: # 22441
Views: 3,127
Hi pharm07,
For Loo-Riegelman you require the ‘true’ elimination from an iv administration. I guess you have it. However, any PK model (and deconvolution based on it) is purely empirical. There is no relationship to physiology.*
Hence, you cannot distinguish between liver first pass and pre-systemic first pass in the gut wall. If you are interested in them, you need PBPK.
❝ How to estimate liver % FPE from Loo-Riegelman (2-compartment) model deconvolution of oral cp time profile data?
For Loo-Riegelman you require the ‘true’ elimination from an iv administration. I guess you have it. However, any PK model (and deconvolution based on it) is purely empirical. There is no relationship to physiology.*
Hence, you cannot distinguish between liver first pass and pre-systemic first pass in the gut wall. If you are interested in them, you need PBPK.
![[image]](img/uploaded/image771.png)
Peters SA. Physiology-Based PK (PBPK). Modeling and Simulations. Wiley, 2012.
- Did you ever wonder why some drugs have a volume of distribution of hundreds (‼) of liters?
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Complete thread:
- Calculation of % Liver FPE pharm07 2021-06-30 05:33 [PK / PD]
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Ing. Helmut Schütz