IV Infusion/Bolus Pk normalisation [Dissolution / BCS / IVIVC]

posted by msmnainar – India, 2021-06-24 09:11 (1008 d 21:56 ago) – Posting: # 22431
Views: 1,542

❝ How to fit pk parameters derived from IV lower strength data with ER/IR/MR/DR higher strength oral formulation data? What are the pk parameters needs to focus?


Hi

Usually AUC is the parameter you can compare, if you are looking to generate absolute bioavailability details. However, your dose selection depends upon the bioavailability of extravascular administration.

However, I dont understand the selection of IV lower strength and oral higher strength. Do you have any correlation on data?

Sundar. M

Complete thread:

UA Flag
Activity
 Admin contact
22,957 posts in 4,819 threads, 1,636 registered users;
89 visitors (0 registered, 89 guests [including 6 identified bots]).
Forum time: 06:07 CET (Europe/Vienna)

With four parameters I can fit an elephant,
and with five I can make him wiggle his trunk.    John von Neumann

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5