Bioequivalence and Bioavailability Forum • IV Infusion/Bolus Pk normalisation

IV Infusion/Bolus Pk normalisation [Dissolution / BCS / IVIVC]

posted by msmnainar – India, 2021-06-24 09:11 (1029 d 23:16 ago) – Posting: # 22431
Views: 1,616

❝ How to fit pk parameters derived from IV lower strength data with ER/IR/MR/DR higher strength oral formulation data? What are the pk parameters needs to focus?

Hi

Usually AUC is the parameter you can compare, if you are looking to generate absolute bioavailability details. However, your dose selection depends upon the bioavailability of extravascular administration.

However, I dont understand the selection of IV lower strength and oral higher strength. Do you have any correlation on data?

—
Sundar. M

Complete thread:

IV Infusion/Bolus Pk normalisation pharm07 2021-06-22 11:09 [Dissolution / BCS / IVIVC]
- IV Infusion/Bolus Pk normalisation drgunasakaran1 2021-06-24 06:07
- IV Infusion/Bolus Pk normalisationmsmnainar 2021-06-24 07:11
  - IV Infusion/Bolus Pk normalisation pharm07 2021-06-24 07:48
    - IV Infusion/Bolus Pk normalisation msmnainar 2021-06-24 19:04
      - IV Infusion/Bolus Pk normalisation pharm07 2021-06-25 04:51