Williams design 3-way [Design Issues]

posted by vezz – Erba (CO), Italy, 2021-06-11 11:11 (1490 d 22:19 ago) – Posting: # 22406
Views: 20,104

Hi Helmut,

in your example you are assuming a model with no period effect, while I am considering the usual model for the analysis of BE studies, including the period effect.

With the period effect included in the model, the estimates of treatment effect are unbiased also using Brus' design.

Kind regards,

Stefano

Complete thread:

UA Flag
Activity
 Admin contact
23,431 posts in 4,931 threads, 1,672 registered users;
79 visitors (2 registered, 77 guests [including 31 identified bots]).
Forum time: 09:30 CEST (Europe/Vienna)

It has yet to be proven
that intelligence has any survival value.    Arthur C. Clarke

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5