Williams design 3-way [Design Issues]

posted by vezz – Erba (CO), Italy, 2021-06-11 09:11 (230 d 00:49 ago) – Posting: # 22406
Views: 3,207

Hi Helmut,

in your example you are assuming a model with no period effect, while I am considering the usual model for the analysis of BE studies, including the period effect.

With the period effect included in the model, the estimates of treatment effect are unbiased also using Brus' design.

Kind regards,

Stefano

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