Williams design 3-way [Design Issues]

posted by vezz – Erba (CO), Italy, 2021-06-11 11:11 (542 d 05:06 ago) – Posting: # 22406
Views: 5,520

Hi Helmut,

in your example you are assuming a model with no period effect, while I am considering the usual model for the analysis of BE studies, including the period effect.

With the period effect included in the model, the estimates of treatment effect are unbiased also using Brus' design.

Kind regards,

Stefano

Complete thread:

UA Flag
Activity
 Admin contact
22,428 posts in 4,694 threads, 1,598 registered users;
14 visitors (0 registered, 14 guests [including 7 identified bots]).
Forum time: 15:18 CET (Europe/Vienna)

Statistics is the art of never having to say you’re wrong.
Variance is what any two statisticians are at.    C.J. Bradfield

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5