Williams design 3-way [Design Issues]

posted by Helmut Homepage – Vienna, Austria, 2021-06-10 20:14 (386 d 03:52 ago) – Posting: # 22405
Views: 4,314

Hi vezz,

» » Unlikely. If you have true period effects, your estimates will be biased and you have no means to correct it.
»
» This is not to support the design proposed by Brus, but it seems to me that with those sequences we should still be able to obtain unbiased estimates of treatment effect also in presence of a period effect (based on the model suggested by the EMA Guideline on BE).

Nope. Let’s consider a simple example. A = B = C = 1, no carryover, additive model.

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