Williams design 3-way [Design Issues]

posted by vezz – Erba (CO), Italy, 2021-06-10 17:23 (101 d 01:28 ago) – Posting: # 22404
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» Unlikely. If you have true period effects, your estimates will be biased and you have no means to correct it.

This is not to support the design proposed by Brus, but it seems to me that with those sequences we should still be able to obtain unbiased estimates of treatment effect also in presence of a period effect (based on the model suggested by the EMA Guideline on BE).

However, for some treatment comparisons the SE will be larger compared to a Latin square design with the same sample size.

I look forward for your thoughts!

Kind regards,

Stefano

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