Bioequivalence and Bioavailability Forum • AUC from 0 to tau at steady state

AUC from 0 to tau at steady state [NCA / SHAM]

posted by d_labes – Berlin, Germany, 2021-06-01 22:31 (1058 d 20:43 ago) – Posting: # 22385
Views: 1,626

Dear Martin,

nice to hear from you. Hope you are healthy.

❝ Should the concentration for time point zero (for calculation of AUC from 0 to tau) be somehow related to the pre-dose concentrations

Yep.

❝ or set to zero

Nope.

❝ where I think setting to zero would be in-line with the principle of superposition (e.g. have a look here).

Don't understand your thinking here.

All the best
Detlew

AUC from 0 to tau at steady state martin 2021-06-01 14:43 [NCA / SHAM]
- AUC from 0 to tau at steady stated_labes 2021-06-01 20:31
- AUC from 0 to tau at steady state Helmut 2021-06-01 22:13