AUC from 0 to tau at steady state [NCA / SHAM]

posted by d_labes  – Berlin, Germany, 2021-06-01 20:31 (117 d 10:34 ago) – Posting: # 22385
Views: 570

Dear Martin,

nice to hear from you. Hope you are healthy.

» Should the concentration for time point zero (for calculation of AUC from 0 to tau) be somehow related to the pre-dose concentrations

Yep.

» or set to zero

Nope.

» where I think setting to zero would be in-line with the principle of superposition (e.g. have a look here).

Don't understand your thinking here.

All the best
Detlew

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