## least common multiple of T and R [Design Issues]

Hi Vishal,

» we are designing the fixed dose combination Immediate release test formulation(A+B) […] 325 mg(B) […] Note than RLD (B) available in EU market in 500 mg strength, 325 mg strength not available as RLD.

» we are designing the fixed dose combination Immediate release test formulation(A+B) […] 325 mg(B) […] Note than RLD (B) available in EU market in 500 mg strength, 325 mg strength not available as RLD.

- There are no reference-listed drugs in Europe.

- Did you bother reading the section I linked in my previous post? BE means always comparing BA of the same doses. An adjustment$$\small{\frac{f_\textrm{T}}{f_\textrm{R}}=\frac{AUC_\textrm{T}\,\cdot D_\textrm{R}}{AUC_\textrm{R}\,\cdot D_\textrm{T}}}$$would not be acceptable.

—

Helmut Schütz

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*Dif-tor heh smusma*🖖_{}Helmut Schütz

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### Complete thread:

- bioequivalence if test and reference formulation having different strengths Vishal S 2021-05-24 09:21 [Design Issues]
- least common multiple of T and R Helmut 2021-05-24 12:32
- least common multiple of T and R Vishal S 2021-05-25 13:26
- least common multiple of T and R drgunasakaran1 2021-05-25 14:22
- least common multiple of T and RHelmut 2021-05-26 00:23

- least common multiple of T and R Vishal S 2021-05-25 13:26

- least common multiple of T and R Helmut 2021-05-24 12:32