If we have any methods to widen CI in parallel design with high variance drug? [RSABE / ABEL]

posted by libaiyi – China, 2021-02-02 10:39 (1120 d 16:49 ago) – Posting: # 22199
Views: 2,072

Dear all,

Recently I meet a problem about sample size of high variance drug, normally, we will design a repeated cross-over trial for this kind of drug. But this time it is designed as a parallel study due to some reasons. But the sample size is too much based on 80%-125% BE CI. So my quesion is if we have any method to widen the CI like RSABE in cross-over study? Thank you very mcuh.:-D

Sincerely,
libaiyi

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