If we have any methods to widen CI in parallel design with high variance drug? [RSABE / ABEL]

posted by libaiyi – China, 2021-02-02 09:39 (513 d 01:42 ago) – Posting: # 22199
Views: 1,341

Dear all,

Recently I meet a problem about sample size of high variance drug, normally, we will design a repeated cross-over trial for this kind of drug. But this time it is designed as a parallel study due to some reasons. But the sample size is too much based on 80%-125% BE CI. So my quesion is if we have any method to widen the CI like RSABE in cross-over study? Thank you very mcuh.:-D

Sincerely,
libaiyi

Complete thread:

UA Flag
Activity
 Admin contact
22,181 posts in 4,647 threads, 1,572 registered users;
online 10 (0 registered, 10 guests [including 3 identified bots]).
Forum time: Thursday 12:22 CEST (Europe/Vienna)

The only way to comprehend what mathematicians mean by Infinity
is to contemplate the extent of human stupidity.    Voltaire

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5