If we have any methods to widen CI in parallel design with high variance drug? [RSABE / ABEL]

posted by libaiyi – China, 2021-02-02 09:39 (179 d 16:09 ago) – Posting: # 22199
Views: 837

Dear all,

Recently I meet a problem about sample size of high variance drug, normally, we will design a repeated cross-over trial for this kind of drug. But this time it is designed as a parallel study due to some reasons. But the sample size is too much based on 80%-125% BE CI. So my quesion is if we have any method to widen the CI like RSABE in cross-over study? Thank you very mcuh.:-D

Sincerely,
libaiyi

Complete thread:

Activity
 Admin contact
21,596 posts in 4,516 threads, 1,532 registered users;
online 3 (0 registered, 3 guests [including 2 identified bots]).
Forum time: Sunday 02:49 CEST (Europe/Vienna)

Sit down before fact as a little child,
be prepared to give up every conceived notion,
follow humbly wherever and whatever abysses nature leads,
or you will learn nothing.    Thomas Henry Huxley

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5