CVintra in replicate designs (→ 2 IBDs) [General Statistics]
Hi clinicalservices,
» We are planning to conduct Steady State study having study design as- T1, T2, R, R.
» What should be our approach for calculation of Intra subject variability for such study design.
What’s the purpose of the study – a pilot study to select either T1 or T2 for a pivotal study?
If yes, see this presentation (slide 22).
Estimate \(\small{CV_\textrm{intra,1}=\sqrt{\exp(MSE_1)-1}}\) and \(\small{CV_\textrm{intra,2}=\sqrt{\exp(MSE_2)-1}}\) from the respective residual mean squares errors \(\small{(MSE_i})\) of the two incomplete block designs containing (1) T1 and R and (2) T2 and R.
» We are planning to conduct Steady State study having study design as- T1, T2, R, R.
» What should be our approach for calculation of Intra subject variability for such study design.
What’s the purpose of the study – a pilot study to select either T1 or T2 for a pivotal study?
If yes, see this presentation (slide 22).
Estimate \(\small{CV_\textrm{intra,1}=\sqrt{\exp(MSE_1)-1}}\) and \(\small{CV_\textrm{intra,2}=\sqrt{\exp(MSE_2)-1}}\) from the respective residual mean squares errors \(\small{(MSE_i})\) of the two incomplete block designs containing (1) T1 and R and (2) T2 and R.
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Dif-tor heh smusma 🖖
Helmut Schütz
![[image]](https://static.bebac.at/img/CC by.png)
The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes
Dif-tor heh smusma 🖖
Helmut Schütz
![[image]](https://static.bebac.at/img/CC by.png)
The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes
Complete thread:
- Intra Subject Variability clinicalservices 2021-01-05 08:19 [General Statistics]
- CVintra in replicate designs (→ 2 IBDs)Helmut 2021-01-05 10:38
- Intra Subject Variability jag009 2021-01-06 00:11