CVintra in replicate designs (→ 2 IBDs) [General Sta­tis­tics]

posted by Helmut Homepage – Vienna, Austria, 2021-01-05 10:38 (10 d 20:05 ago) – Posting: # 22176
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Hi clinicalservices,

» We are planning to conduct Steady State study having study design as- T1, T2, R, R.
» What should be our approach for calculation of Intra subject variability for such study design.

What’s the purpose of the study – a pilot study to select either T1 or T2 for a pivotal study?
If yes, see this presentation (slide 22).

Estimate \(\small{CV_\textrm{intra,1}=\sqrt{\exp(MSE_1)-1}}\) and \(\small{CV_\textrm{intra,2}=\sqrt{\exp(MSE_2)-1}}\) from the respective residual mean squares errors \(\small{(MSE_i})\) of the two incomplete block designs containing (1) T1 and R and (2) T2 and R.

Dif-tor heh smusma 🖖
Helmut Schütz
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