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RegisterSimeticone soft gel capsule dissolution problem [Dissolution / BCS / IVIVC]
Dear mahonny,
I read your complete post and surprise to see that you also face the same problem which we also facing in 2021.
We are also working on a similar kind of formulation where we also did the same trials as you mentioned.
Since you posted a very long time ago, so I hope you find out the solution for the SImethicone problem in Dissolution.
We are thinking to use USP Type III apparatus or looking to skip dissolution since there is very little absorption reported in the available literature.
Edit: Full quote removed. Please delete everything from the text of the original poster which is not necessary in understanding your answer; see also this post #5! [Ohlbe]
I read your complete post and surprise to see that you also face the same problem which we also facing in 2021.
We are also working on a similar kind of formulation where we also did the same trials as you mentioned.
Since you posted a very long time ago, so I hope you find out the solution for the SImethicone problem in Dissolution.
We are thinking to use USP Type III apparatus or looking to skip dissolution since there is very little absorption reported in the available literature.
Edit: Full quote removed. Please delete everything from the text of the original poster which is not necessary in understanding your answer; see also this post #5! [Ohlbe]
Complete thread:
- Simeticone soft gel capsule dissolution problem mahonny 2015-03-31 13:12 [Dissolution / BCS / IVIVC]
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- Simeticone soft gel capsule dissolution problemTusharC 2021-01-04 08:21
Ing. Helmut Schütz