Significant effects [General Sta­tis­tics]

posted by Moloko – Russia, 2020-12-22 11:41 (308 d 20:34 ago) – Posting: # 22153
Views: 1,077

Hi all,

Could somebody help me with my doubts about significant sequence/treatment/period
effects in BE study? I got the following anova results in 2x2x4 design:

                 DF Sum Sq Mean Sq      F   P-val
sequence          1  0.558   0.558 10.269   0.002
period            3  0.566   0.189  3.472   0.021
treatment         1  0.075   0.075  1.384   0.244
sequence:subject 23  7.632   0.332  6.102  <0.001
residual         69  3.752   0.054


My СI-s are within the range of 80.000% - 125.000%, so formally BE acceptance criterion is met. But these p-values scare me... :confused:

I don't have much experience in BE and I think it is not good then period or sequence factor influences PK-parameter.

thanks!


Edit: Category changed; see also this post #1. Tabulators changed to spaces and BBcoded; see also this post #6. [Helmut]

Complete thread:

Activity
 Admin contact
21,758 posts in 4,550 threads, 1,545 registered users;
online 8 (0 registered, 8 guests [including 4 identified bots]).
Forum time: Wednesday 09:15 CEST (Europe/Vienna)

There ain’t no rules around here!
We’re trying to accomplish something!    Thomas Alva Edison

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5