Significant effects [General Sta­tis­tics]

posted by Moloko – Russia, 2020-12-22 11:41 (120 d 00:49 ago) – Posting: # 22153
Views: 720

Hi all,

Could somebody help me with my doubts about significant sequence/treatment/period
effects in BE study? I got the following anova results in 2x2x4 design:

                 DF Sum Sq Mean Sq      F   P-val
sequence          1  0.558   0.558 10.269   0.002
period            3  0.566   0.189  3.472   0.021
treatment         1  0.075   0.075  1.384   0.244
sequence:subject 23  7.632   0.332  6.102  <0.001
residual         69  3.752   0.054


My СI-s are within the range of 80.000% - 125.000%, so formally BE acceptance criterion is met. But these p-values scare me... :confused:

I don't have much experience in BE and I think it is not good then period or sequence factor influences PK-parameter.

thanks!


Edit: Category changed; see also this post #1. Tabulators changed to spaces and BBcoded; see also this post #6. [Helmut]

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