Significant effects [General Sta­tis­tics]

posted by Moloko – Russia, 2020-12-22 12:41 (1162 d 05:49 ago) – Posting: # 22153
Views: 2,163

Hi all,

Could somebody help me with my doubts about significant sequence/treatment/period
effects in BE study? I got the following anova results in 2x2x4 design:

                 DF Sum Sq Mean Sq      F   P-val
sequence          1  0.558   0.558 10.269   0.002
period            3  0.566   0.189  3.472   0.021
treatment         1  0.075   0.075  1.384   0.244
sequence:subject 23  7.632   0.332  6.102  <0.001
residual         69  3.752   0.054


My СI-s are within the range of 80.000% - 125.000%, so formally BE acceptance criterion is met. But these p-values scare me... :confused:

I don't have much experience in BE and I think it is not good then period or sequence factor influences PK-parameter.

thanks!


Edit: Category changed; see also this post #1. Tabulators changed to spaces and BBcoded; see also this post #6. [Helmut]

Complete thread:

UA Flag
Activity
 Admin contact
22,912 posts in 4,806 threads, 1,636 registered users;
22 visitors (0 registered, 22 guests [including 4 identified bots]).
Forum time: 18:31 CET (Europe/Vienna)

It is the peculiar and perpetual error of the human understanding
to be more moved and excited by affirmatives than negatives.    Francis Bacon

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5