Bioequivalence and Bioavailability Forum • Different sampling time points and Blinding

Different sampling time points and Blinding [Bioanalytics]

posted by Helmut – Vienna, Austria, 2020-12-11 17:44 (655 d 05:12 ago) – Posting: # 22145
Views: 1,450

Hi ElMaestro,

» » Keep the number of time points equal and give the sequence of samples (1, 2, …, n) and not the time points themselves (t₁, t₂, …, t_n) on the vials’ label.
»
» […] I guess one could pad the series holding only 20 samples with a sample 21 and 22 based on extracted un-spiked plasma. That would kind of win the olympic gold, wouldn't it?

Perhaps silver.

» The analyst will presumably be able to tell nothing about the nature of samples due to just the number of samples per series […].

Evidently, my dear Dr Watson. But: Sooner or later a smart analyst would start to wonder why in one period the last two samples are always BLQ.

—
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Helmut Schütz

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Complete thread:

Different sampling time points and Blinding Pharma_88 2020-12-11 05:22 [Bioanalytics]
- Different sampling time points and Blinding Helmut 2020-12-11 10:38
  - Different sampling time points and Blinding ElMaestro 2020-12-11 11:07
    - Different sampling time points and BlindingHelmut 2020-12-11 17:44
      - Different sampling time points and Blinding ElMaestro 2020-12-11 21:57
        
        Blinding… Helmut 2020-12-12 12:06