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RegisterEstimate the sample size HVD [RSABE / ABEL]
Dear all
Still fashionable HVD theme, question.
Am I correct in understanding that if in the literature, for example, CV = 50% for AUC is found as the largest (for Cmax it is also more than 30%, but less than for AUC), then it will not be correct to use sampleN.scABEL to estimate the sample size? There will be no equivalence limits scaling for this parameter. And on the other hand, for the parameter Cmax there will be conditions of forced bioequivalence, since the sample size will be at least twice the allowable size calculated by the AUC parameter. How to proceed?
Regards
Still fashionable HVD theme, question.
Am I correct in understanding that if in the literature, for example, CV = 50% for AUC is found as the largest (for Cmax it is also more than 30%, but less than for AUC), then it will not be correct to use sampleN.scABEL to estimate the sample size? There will be no equivalence limits scaling for this parameter. And on the other hand, for the parameter Cmax there will be conditions of forced bioequivalence, since the sample size will be at least twice the allowable size calculated by the AUC parameter. How to proceed?
Regards
Complete thread:
- Estimate the sample size HVDYura 2020-12-03 08:47
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- AUC (by ABE) and Cmax (by ABEL): power Helmut 2020-12-03 12:34
- AUC (by ABE) and Cmax (by ABEL): power Yura 2020-12-04 08:11
- AUC (by ABE) and Cmax (by ABEL): power Helmut 2020-12-03 12:34
Ing. Helmut Schütz