Bioequivalence and Bioavailability Forum • Sample sizes (ignoring the inflated TIE)

Sample sizes (ignoring the inflated TIE) [RSABE / ABEL]

posted by Helmut – Vienna, Austria, 2020-11-29 12:21 (1097 d 15:34 ago) – Posting: # 22092
Views: 5,409

Dear Detlew,

❝ there is no need to define and program a new function :cool: !

Great!

library(PowerTOST) design <- "2x2x4" regGCC <- reg_const("user", r_const = log(1/0.75)/CV2se(0.3), CVswitch = 0.3, CVcap = 0.3, pe_const = TRUE) CV <- sort(c(seq(0.2, 0.6, 0.1), 0.301)) res <- data.frame(CV = CV, L.EMA = scABEL(CV, regulator = "EMA")[, 1], U.EMA = scABEL(CV, regulator = "EMA")[, 2], n.EMA = NA, L.GCC = scABEL(CV, regulator = regGCC)[, 1], U.GCC = scABEL(CV, regulator = regGCC)[, 2], n.GCC = NA) for (j in 1:nrow(res)) { res$n.EMA[j] <- sampleN.scABEL(CV = CV[j], design = design, regulator = "EMA", details = FALSE, print = FALSE)[["Sample size"]] res$n.GCC[j] <- sampleN.scABEL(CV = CV[j], design = design, regulator = regGCC, details = FALSE, print = FALSE)[["Sample size"]] } print(res, row.names = FALSE) CV L.EMA U.EMA n.EMA L.GCC U.GCC n.GCC 0.200 0.8000000 1.250000 18 0.80 1.250000 18 0.300 0.8000000 1.250000 34 0.75 1.333333 28 0.301 0.7994604 1.250844 34 0.75 1.333333 28 0.400 0.7461770 1.340165 30 0.75 1.333333 30 0.500 0.6983678 1.431910 28 0.75 1.333333 42 0.600 0.6983678 1.431910 32 0.75 1.333333 58

PS: Do we have a bug in scABEL()?

CV <- c(0.3, 0.3+10^(-6:-2)) lim <- scABEL(CV) res <- data.frame(CV = CV, L = lim[, 1], U = lim[, 2]) print(res, row.names = FALSE) CV L U 0.300000 0.8000000 1.250000 0.300001 0.8000296 1.249954 0.300010 0.8000244 1.249962 0.300100 0.7999731 1.250042 0.301000 0.7994604 1.250844 0.310000 0.7943616 1.258873

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Helmut Schütz

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Complete thread:

Inflated type I error with fixed widened limits? Helmut 2020-11-25 10:50 [RSABE / ABEL]
- Inflated type I error with fixed widened limits? d_labes 2020-11-25 15:07
  - Inflated type I error with fixed widened limits? Helmut 2020-11-26 00:09
    - Inflated type I error with fixed widened limits d_labes 2020-11-26 15:38
      - Inflated type I error: Not nice Helmut 2020-11-26 17:14
        
        Power of the GCC framework and power of PowerTOST d_labes 2020-11-28 11:20
        
        Sample sizes (ignoring the inflated TIE)Helmut 2020-11-29 11:21
        
        Bug? d_labes 2020-11-29 16:22
        
        “Feature” Helmut 2020-11-30 00:16
- Inflated type I error with fixed widened limits? wienui 2020-11-29 14:03
  - Inflated type I error with fixed widened limits d_labes 2020-11-29 17:51
    - Inflated type I error with fixed widened limits Helmut 2020-11-30 00:14
      - Inflated type I error with fixed widened limits wienui 2020-11-30 03:30
        
        Houston, we have a problem! Helmut 2020-11-30 14:42
        
        Paradox of tolerance Astea 2020-12-01 23:34
        
        Οὐτοπεία ∨ Εὐτοπεία Helmut 2020-12-02 01:37
        
        Uchronia Astea 2020-12-02 09:46
        
        Steampunk Helmut 2020-12-02 11:34
        
        Dieselpunk Astea 2020-12-02 15:28
        
        Dieselpunk Helmut 2020-12-02 16:18
        
        Steampunk? OT d_labes 2020-12-02 19:30
        
        Steampunk? OT Astea 2020-12-02 19:58
        
        PowerTOST 1.5-2.9000 on GitHub Helmut 2020-12-23 12:18