Inflated type I error: Not nice [RSABE / ABEL]

posted by Helmut Homepage – Vienna, Austria, 2020-11-26 18:14 (1188 d 00:35 ago) – Posting: # 22088
Views: 5,821

Dear Detlew,

❝ ❝ Shit.

❝ Why shit?

Cause it slipped through my attention for almost fifteen years… In South Africa for Cmax fixed limits of 75.00–133.33% may be used (no replicate design needed).

❝ ❝ ❝ Quick and dirty captured code from power.scABEL.sds.

❝ ❝

❝ ❝ How, did you do that? That’s beyond me.

❝ Stolen the code of subject data sims and scaled ABE evaluation in the working horse function .pwr.SABE.sds().

❝ Have a look into the code of the new but undocumented function power.fwl.sds() in the GitHub repository.


❝ ❝ ...And got 20.568% after eleven (!) hours.

❝ Wow! 11 hours for one number! 106 sims in ca. 4-5 sec with my implementation.

Mühsam ernährt sich das Eichhörnchen.

❝ Some results with setseed=FALSE:

power.fwl.sds(CV=0.3, n=40, theta0=0.8, design="2x2x4", setseed=F)

❝ 0.2045, 0.2066, 0.2047, 0.2051, 0.2082

❝ Seems we are simulating the same number :cool:.


Terrible for drugs which are not highly variable (reminds me on the FDA’s RSABE). The design is less important.

[image] 2-sequence 4-period (full) replicates

[image] 2-sequence 3-period (full) replicates

[image] 3-sequence 3-period (partial) replicates

Dif-tor heh smusma 🖖🏼 Довге життя Україна! [image]
Helmut Schütz

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