Couple of sample size questions [Power / Sample Size]

posted by BE-proff – Russia, 2020-11-04 07:21 (190 d 21:21 ago) – Posting: # 22054
Views: 803

Hi All :waving:

I have a couple of questions:
  1. I wanna do BE study in european population but all PK data from literature have been obtained from asian volunteers.
    Is it applicable/correct to use such data for my study sample size calculation? :confused:

  2. We know that the higher number of subjects the higher chances to pass BE. But on the other hand higher subjects will need higher budget which is not good.
    Are there any statstical methods to find the optimal decision in such situations? :ponder:

Complete thread:

Activity
 Admin contact
21,460 posts in 4,486 threads, 1,511 registered users;
online 5 (0 registered, 5 guests [including 5 identified bots]).
Forum time: Friday 04:43 UTC (Europe/Vienna)

Art is “I”; science is “we”.    Claude Bernard

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5