Sample size based on worst case [Power / Sample Size]

posted by Helmut Homepage – Vienna, Austria, 2020-10-19 18:17 (829 d 12:30 ago) – Posting: # 22030
Views: 1,438

Hi Researcher101,

❝ […] sample size in multiple dose studies? Should I estimate sample size based on intra subject variability of Cmin or Cmax or C tau?


Based on the one with highest variability – if the assumed T/R-ratios are identical. If not, explore various combinations and opt for the worst case. This gives you a safety margin for the other PK metrics.

❝ Can I pool the CVs to estimate sample size?


Doesn’t make any sense.

Dif-tor heh smusma 🖖🏼 Довге життя Україна! [image]
Helmut Schütz
[image]

The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes

Complete thread:

UA Flag
Activity
 Admin contact
22,477 posts in 4,708 threads, 1,603 registered users;
14 visitors (0 registered, 14 guests [including 5 identified bots]).
Forum time: 05:48 CET (Europe/Vienna)

In these matters the only certainty is
that nothing is certain.    Pliny the Elder

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5