Sample size based on worst case [Power / Sample Size]

posted by Helmut Homepage – Vienna, Austria, 2020-10-19 16:17 (46 d 15:51 ago) – Posting: # 22030
Views: 348

Hi Researcher101,

» […] sample size in multiple dose studies? Should I estimate sample size based on intra subject variability of Cmin or Cmax or C tau?

Based on the one with highest variability – if the assumed T/R-ratios are identical. If not, explore various combinations and opt for the worst case. This gives you a safety margin for the other PK metrics.

» Can I pool the CVs to estimate sample size?

Doesn’t make any sense.

Dif-tor heh smusma 🖖
Helmut Schütz
[image]

The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes

Complete thread:

Activity
 Admin contact
21,240 posts in 4,431 threads, 1,482 registered users;
online 5 (0 registered, 5 guests [including 2 identified bots]).
Forum time: Saturday 07:09 CET (Europe/Vienna)

I believe there is no philosophical high-road in science,
with epistemological signposts. No, we are in a jungle
and find our way by trial and error,
building our road behind us as we proceed.    Max Born

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5