Log in
RegisterSample size based on worst case [Power / Sample Size]
posted by Helmut 
– Vienna, Austria, 2020-10-19 18:17 (1719 d 15:24 ago) – Posting: # 22030
Views: 3,794
Hi Researcher101,
Based on the one with highest variability – if the assumed T/R-ratios are identical. If not, explore various combinations and opt for the worst case. This gives you a safety margin for the other PK metrics.
Doesn’t make any sense.
❝ […] sample size in multiple dose studies? Should I estimate sample size based on intra subject variability of Cmin or Cmax or C tau?
Based on the one with highest variability – if the assumed T/R-ratios are identical. If not, explore various combinations and opt for the worst case. This gives you a safety margin for the other PK metrics.
❝ Can I pool the CVs to estimate sample size?
Doesn’t make any sense.
—
Dif-tor heh smusma 🖖🏼 Довге життя Україна!![[image]](https://static.bebac.at/pics/Blue_and_yellow_ribbon_UA.png)
Helmut Schütz
![[image]](https://static.bebac.at/img/CC by.png)
The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes
Dif-tor heh smusma 🖖🏼 Довге життя Україна!
Helmut Schütz
The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes
Complete thread:
- Multiple dose design Sample size Researcher101 2020-10-14 10:21
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- CV of Css,max ≤ CV of Cmax Helmut 2020-10-14 11:27
- Multiple dose design Sample size Researcher101 2020-10-14 13:37
- Sample size based on worst caseHelmut 2020-10-19 16:17
- Multiple dose design Sample size dshah 2020-10-20 06:43
Ing. Helmut Schütz