Sample size based on worst case [Power / Sample Size]

posted by Helmut Homepage – Vienna, Austria, 2020-10-19 16:17 (206 d 19:47 ago) – Posting: # 22030
Views: 601

Hi Researcher101,

» […] sample size in multiple dose studies? Should I estimate sample size based on intra subject variability of Cmin or Cmax or C tau?

Based on the one with highest variability – if the assumed T/R-ratios are identical. If not, explore various combinations and opt for the worst case. This gives you a safety margin for the other PK metrics.

» Can I pool the CVs to estimate sample size?

Doesn’t make any sense.

Dif-tor heh smusma 🖖
Helmut Schütz
[image]

The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes

Complete thread:

Activity
 Admin contact
21,460 posts in 4,486 threads, 1,513 registered users;
online 14 (1 registered, 13 guests [including 4 identified bots]).
Forum time: Friday 12:04 CEST (Europe/Vienna)

Art is “I”; science is “we”.    Claude Bernard

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5