Sample size based on worst case [Power / Sample Size]

posted by Helmut Homepage – Vienna, Austria, 2020-10-19 16:17 (617 d 19:01 ago) – Posting: # 22030
Views: 1,211

Hi Researcher101,

» […] sample size in multiple dose studies? Should I estimate sample size based on intra subject variability of Cmin or Cmax or C tau?

Based on the one with highest variability – if the assumed T/R-ratios are identical. If not, explore various combinations and opt for the worst case. This gives you a safety margin for the other PK metrics.

» Can I pool the CVs to estimate sample size?

Doesn’t make any sense.

Dif-tor heh smusma 🖖 [image]
Helmut Schütz
[image]

The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes

Complete thread:

UA Flag
Activity
 Admin contact
22,180 posts in 4,647 threads, 1,572 registered users;
online 12 (2 registered, 10 guests [including 6 identified bots]).
Forum time: Wednesday 11:18 CEST (Europe/Vienna)

Nerds don’t just happen to dress informally.
They do it too consistently.
Consciously or not, they dress informally
as a prophylactic measure against stupidity.    Paul Graham

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5