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RegisterMultiple dose design Sample size [Power / Sample Size]
Also if Cmax ss within variability is around 20 % and Cmin ss within variability is around 41 % on which one should I depend
Dears, I am asking about the factor we determine the sample size in multiple dose studies? Should I estimate sample size based on intra subject variability of Cmin or Cmax or C tau?
Can I pool the CVs to estimate sample size?
Edit: Full quote removed. Please delete everything from the text of the original poster which is not necessary in understanding your answer; see also this post #5! [Ohlbe]
Edit: Post merged with a new (deleted) post of 2020-10-19. Relax; see also this post #9. [Helmut]
Dears, I am asking about the factor we determine the sample size in multiple dose studies? Should I estimate sample size based on intra subject variability of Cmin or Cmax or C tau?
Can I pool the CVs to estimate sample size?
Edit: Full quote removed. Please delete everything from the text of the original poster which is not necessary in understanding your answer; see also this post #5! [Ohlbe]
Edit: Post merged with a new (deleted) post of 2020-10-19. Relax; see also this post #9. [Helmut]
Complete thread:
- Multiple dose design Sample size Researcher101 2020-10-14 10:21
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- CV of Css,max ≤ CV of Cmax Helmut 2020-10-14 11:27
- Multiple dose design Sample sizeResearcher101 2020-10-14 13:37
- Sample size based on worst case Helmut 2020-10-19 16:17
- Multiple dose design Sample size dshah 2020-10-20 06:43
Ing. Helmut Schütz