CV of Css,max ≤ CV of Cmax [Power / Sample Size]

posted by Helmut Homepage – Vienna, Austria, 2020-10-14 13:27 (1261 d 05:37 ago) – Posting: # 21999
Views: 2,036

Hi Researcher101,

if you have the CV of Cmax from a MD study that’s best, of course.

❝ Also is it in the safe side to estimate sample size based on Cmax single dose not multiple dose?


Yes, since generally (I know only one published exception*) variability in steady state is ≤ the one after a single dose.



Dif-tor heh smusma 🖖🏼 Довге життя Україна! [image]
Helmut Schütz
[image]

The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes

Complete thread:

UA Flag
Activity
 Admin contact
22,957 posts in 4,819 threads, 1,638 registered users;
78 visitors (0 registered, 78 guests [including 9 identified bots]).
Forum time: 18:05 CET (Europe/Vienna)

Nothing shows a lack of mathematical education more
than an overly precise calculation.    Carl Friedrich Gauß

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5