CV of Css,max ≤ CV of Cmax [Power / Sample Size]

posted by Helmut Homepage – Vienna, Austria, 2020-10-14 11:27 (215 d 04:31 ago) – Posting: # 21999
Views: 730

Hi Researcher101,

if you have the CV of Cmax from a MD study that’s best, of course.

» Also is it in the safe side to estimate sample size based on Cmax single dose not multiple dose?

Yes, since generally (I know only one published exception*) variability in steady state is ≤ the one after a single dose.

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Helmut Schütz

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