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RegisterParallel design from crossover CV [Power / Sample Size]
Greetings to all !!
Hope all of you are safe in this pandemic situation
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Mostly in public domain, the inter subject CV of drug is not mentioned. Either intra-subject cv or confidence interval ranges are mentioned. So can we use this intra-subject CV to estimate sample size for parallel study design?
Is there any formula to calculate inter-subject CV using 90% confidence interval ranges and number of subjects?
First can we calculate the sample size of 2 way crossover study design and then double the subjects and finalize the sample size for parallel study design?
Please suggest.
Stay Safe.
Thank You
Edit: Category changed; see also this post #1. Subject line changed; see also this post #2. [Helmut]
Hope all of you are safe in this pandemic situation
.Mostly in public domain, the inter subject CV of drug is not mentioned. Either intra-subject cv or confidence interval ranges are mentioned. So can we use this intra-subject CV to estimate sample size for parallel study design?
Is there any formula to calculate inter-subject CV using 90% confidence interval ranges and number of subjects?
First can we calculate the sample size of 2 way crossover study design and then double the subjects and finalize the sample size for parallel study design?
Please suggest.
Stay Safe.
Thank You
Edit: Category changed; see also this post #1. Subject line changed; see also this post #2. [Helmut]
Complete thread:
- Parallel design from crossover CVarl_stat 2020-10-14 06:39 [Power / Sample Size]
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- No relationship between inter- and intra-subject CV Helmut 2020-10-14 11:00
- No relationship between inter- and intra-subject CV arl_stat 2020-10-14 15:02
- No relationship between inter- and intra-subject CV Helmut 2020-10-14 11:00
Ing. Helmut Schütz