Parallel design from crossover CV [Power / Sample Size]

posted by arl_stat – India, 2020-10-14 04:39 (215 d 08:37 ago) – Posting: # 21996
Views: 1,135

Greetings to all !!

Hope all of you are safe in this pandemic situation:-).

Mostly in public domain, the inter subject CV of drug is not mentioned. Either intra-subject cv or confidence interval ranges are mentioned. So can we use this intra-subject CV to estimate sample size for parallel study design?

Is there any formula to calculate inter-subject CV using 90% confidence interval ranges and number of subjects?

First can we calculate the sample size of 2 way crossover study design and then double the subjects and finalize the sample size for parallel study design?

Please suggest.


Stay Safe.

Thank You :-)


Edit: Category changed; see also this post #1. Subject line changed; see also this post #2[Helmut]

Complete thread:

Activity
 Admin contact
21,462 posts in 4,487 threads, 1,514 registered users;
online 13 (0 registered, 13 guests [including 5 identified bots]).
Forum time: Monday 13:16 UTC (Europe/Vienna)

Garbage in, garbage out.
It’s very very simple.    Anders Fuglsang

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5