4 periods (BE fed & fasting) [General Sta­tis­tics]

posted by Helmut Homepage – Vienna, Austria, 2020-10-13 01:58 (1263 d 02:19 ago) – Posting: # 21995
Views: 1,399

Hi Loky do,

do you mean sumfink like this?
If yes, perform two separate ANOVAs on part 1 (T vs R in fed state: periods 1 & 2) and part 2 (T vs R in fasting state: periods 3 & 4).
To assess the food effects (fed vs fasting) of T and R employ two separate paired comparisons. Here you have to assume no period effects – state that in the protocol. However, you will not loose the war on this if you succeeded in showing BE in fed and fasting state. There are no commonly accepted rules to decide whether food effects are different. In my studies I assess whether the CIs overlap.

Homework: Find out why I recommend fed state first. ;-)

Dif-tor heh smusma 🖖🏼 Довге життя Україна! [image]
Helmut Schütz
[image]

The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes

Complete thread:

UA Flag
Activity
 Admin contact
22,957 posts in 4,819 threads, 1,636 registered users;
67 visitors (0 registered, 67 guests [including 3 identified bots]).
Forum time: 03:18 CET (Europe/Vienna)

With four parameters I can fit an elephant,
and with five I can make him wiggle his trunk.    John von Neumann

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5