Dextromethorphan [Dissolution / BCS / IVIVC]

posted by begoña – Spain, 2020-10-08 10:35 (17 d 04:00 ago) – Posting: # 21979
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» Dextromethorphan hydrobromide belongs to the class II of biopharmaceutics classification system (BCS), exhibits low solubility and high permeability.

Thanks
I read papers where it has classified as Class II, but also I found several publications that describe Dextromehorphan HBr as very high soluble substance.

I was wondering if I could ask for a biowaiver, during the evaluation of an oral product containig dexthrometorphan.


Edit: Full quote removed. Please delete everything from the text of the original poster which is not necessary in understanding your answer; see also this post #5[Helmut]

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