Bioequivalence and Bioavailability Forum • Internal Standard Variation

Internal Standard Variation [Bioanalytics]

posted by ElMaestro – Denmark, 2008-08-15 18:51 (6511 d 17:46 ago) – Posting: # 2192
Views: 17,187

It never hurts to have an SOP. Set limits for IS-variability. In addition, perhaps limits for a non-param. correlation coefficient would be accepable (Spearman's rank or Kendall's tau; "With X samples per run, IS-response as function of sample number should not have an absolute corr. coeff. larger than 0.whatever" or something like that)???

Oder was?

OK: This would work if the IS response follows a unimodal trend. But might not work if the IS-response has one or more extrema.

EM.

Complete thread:

Internal Standard Variation Dr. Harish L. Rao 2007-09-08 14:16 [Bioanalytics]
- Internal Standard Variation Helmut 2007-09-08 16:43
  - Internal Standard Variation Ohlbe 2007-09-08 22:32
    - Internal Standard Variation Helmut 2007-09-09 00:37
      - Internal Standard Variation Charl 2007-09-09 12:25
        
        Internal Standard Variation Jaime_R 2007-09-09 13:13
        
        IS vs ES methods Helmut 2007-09-09 15:05
        Internal Standard Variation Charl 2007-09-10 10:10
        
        Internal Standard Variation Jaime_R 2007-09-10 18:58
      - Internal Standard Variation Ohlbe 2007-09-09 23:20
        
        Internal Standard Variation Helmut 2007-09-10 20:33
- Internal Standard Variation vamshi 2008-08-14 12:33
  - Internal Standard Variation ElMaestro 2008-08-14 14:09
    - Internal Standard Variation Helmut 2008-08-14 20:28
      - Internal Standard VariationElMaestro 2008-08-15 16:51
        
        Internal Standard Variation Helmut 2008-08-15 17:29