Bioequivalence and Bioavailability Forum

Hi ElMaestro,

❝ ❝ A correlation >1 is funny.

❝

❝ In a way you can compare it with the CoA of a reference standard which is labeled with purity = 101.2 %. It does not contain 101.2% - I guarantee it - but that may stil be the most viable estimate.

That’s another cup of tea. I guarantee that it can contain exactly 101.2% indeed – regardless what the CoA says.

❝ It is all about how we estimate / measure it. We are not guaranteed to get the same model maximum likelihood if you keep the rho controlled between (exactly) -1 to (exactly) 1 with any iterative method regardless of your tolerance setting on the x- or y-scale.

Here you are right despite some weirdos laments.* The largest correlation in my 500 simulated data sets was for #168 with 7.285 (‼)…

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• Schütz H. An extremely strange observation? [letter]. Europ J Drug Metabol Pharmacokin. 2004;29(1):69–71. doi:10.1007/BF03190576.