Bioequivalence and Bioavailability Forum

Hi Hötzi,

thanks for WNL outputs with various covariance structures.

❝ A correlation >1 is funny.

In a way you can compare it with the CoA of a reference standard which is labeled with purity = 101.2 %. It does not contain 101.2% - I guarantee it - but that may stil be the most viable estimate.
It is all about how we estimate / measure it. We are not guaranteed to get the same model maximum likelihood if you keep the rho controlled between (exactly) -1 to (exactly) 1 with any iterative method regardless of your tolerance setting on the x- or y-scale.